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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1686427Generated: October 26, 2026

2-[3-Hydroxy-5-(trifluoromethyl)phenyl]propanoic acid → 2-[3-{2-Chloro-4-[(4-fluorobenzyl)sulfonyl]phenoxy}-5-(trifluoromethyl)phenyl]propanoic acid

https://huagongshe.com/reaction/1686427

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-[3-Hydroxy-5-(trifluoromethyl)phenyl]propanoic acidHCID 66734097—
Reactant2-Chloro-1-fluoro-4-[(4-fluorobenzyl)sulfonyl]benzeneHCID 68953429—
Product2-[3-{2-Chloro-4-[(4-fluorobenzyl)sulfonyl]phenoxy}-5-(trifluoromethyl)phenyl]propanoic acidHCID 16123538—

Reaction Steps

The title compound was prepared as described in example 2 step (iii) but instead using the product from example 50 step (iii) and the product from example 34 step (i).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08148572B2
Source datasetuspto-grants-2012_04
ORD IDord-ef5c8e05d8c64f6bac6446f5a515a184
Source noteuspto-grants-2012_04