反应详情

Lithium aluminium hydride (1M in THF, 22.07 ml) was added dropwise to a stirred solution of the product of step (ii) (5.1 g) in THF (50 ml) at 0° C. and stirred at RT overnight. The reaction was quenched in 2M HCl, extracted with ether, dried (MgSO4) and evaporated under reduced pressure to give an oil, which was purified by flash column chromatography (eluent 1:1 isohexane/diethylether) to give the subtitle compound (5.38 g).

1. customThe reaction was quenched in 2M HCl
2. extractionextracted with ether
3. dry with materialdried (MgSO4)
4. customevaporated under reduced pressure
5. customto give an oil, which
6. customwas purified by flash column chromatography (eluent 1:1 isohexane/diethylether)