反应详情

温度

100 °C

The product of step (iv) (4.5 g), in glacial acetic acid (30 ml) was treated with 48% aqueous HBr (30 ml) and heated at 100° C. for 24 h. The reaction mixture was partitioned between water and ethyl acetate, the organics were separated then dried (MgSO4) and evaporated under reduced pressure to give a tan solid which was triturated with ether/isohexane (4.24 g).

1. customThe reaction mixture was partitioned between water and ethyl acetate
2. customthe organics were separated
3. dry with materialthen dried (MgSO4)
4. customevaporated under reduced pressure
5. customto give a tan solid which
6. customwas triturated with ether/isohexane (4.24 g)