HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → [3-{[(Dimethylamino)carbonothioyl]oxy}-5-(trifluoromethyl)phenyl]acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Dimethylthiocarbamoyl chloride | HCID 27871 | — |
| Reactant | 3-Hydroxy-5-(trifluoromethyl)phenylacetic acid | HCID 69065624 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | [3-{[(Dimethylamino)carbonothioyl]oxy}-5-(trifluoromethyl)phenyl]acetic acid | HCID 86625039 | — |
Reaction Steps
The product from example 25 step (iv) (0.5 g), dimethylthiocarbamoyl chloride (0.32 ml), DMAP (0.026 g) and triethylamine (0.60 ml) in dry dioxane (10 ml) were stirred at 100° C. for 15 h. The mixture was diluted with water, extracted with ethyl acetate, dried (MgSO4) and evaporated under reduced pressure to an oil. The oil was purified by flash column chromatography (eluent ether) to give the subtitle compound (0.52 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08148572B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-d2d965d649a74f638088da9a869bd329 |
| Source note | uspto-grants-2012_04 |