反应详情

The product from example 25 step (iv) (0.5 g), dimethylthiocarbamoyl chloride (0.32 ml), DMAP (0.026 g) and triethylamine (0.60 ml) in dry dioxane (10 ml) were stirred at 100° C. for 15 h. The mixture was diluted with water, extracted with ethyl acetate, dried (MgSO4) and evaporated under reduced pressure to an oil. The oil was purified by flash column chromatography (eluent ether) to give the subtitle compound (0.52 g).

1. extractionextracted with ethyl acetate
2. dry with materialdried (MgSO4)
3. customevaporated under reduced pressure to an oil
4. customThe oil was purified by flash column chromatography (eluent ether)