Sodium Hydroxide → HCID 66734305, compound

HRID 1686439Notes

Reaction equation

HRID 1686439 reaction equation
CN(C)C([S:5][C:6]1[CH:7]=[C:8]([CH2:16][C:17]([OH:19])=[O:18])[CH:9]=[C:10]([C:12]([F:15])([F:14])[F:13])[CH:11]=1)=O.[OH-].[Na+]>CO.Cl>[SH:5][C:6]1[CH:7]=[C:8]([CH2:16][C:17]([OH:19])=[O:18])[CH:9]=[C:10]([C:12]([F:15])([F:14])[F:13])[CH:11]=1

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 86625040HCID 86625040, compound

Product 1

HCID 66734305HCID 66734305, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 887MethanolSolvent

Procedure

The product from step (ii) (0.49 g) was dissolved in methanol (10 ml) and 2M NaOH (10 ml) and stirred at RT overnight. The mixture was diluted with 2M HCl, extracted with ethyl acetate, dried (MgSO4) and evaporated under reduced pressure to an solid (0.30 g)

Workup

  1. extractionextracted with ethyl acetate
  2. dry with materialdried (MgSO4)
  3. customevaporated under reduced pressure to an solid (0.30 g)

Sources & evidence

ORD record
ord-f29d212cdfdc4ffd810657908030c68e
Source dataset
uspto-grants-2012_04
Patent number
US08148572B2

Reaction notes

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