Benzene → (3-Chloro-4-fluorophenyl)(phenyl)methanone

HRID 1686447Notes

Reaction equation

HRID 1686447 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[F:11])[C:5](Cl)=[O:6].[CH:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>O>[Cl:1][C:2]1[CH:3]=[C:4]([C:5]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[O:6])[CH:8]=[CH:9][C:10]=1[F:11]

Participants

4

Reactant 2

HCID 241BenzeneHCID 27365483-Chloro-4-fluorobenzoyl Chloride

Product 1

HCID 15023215(3-Chloro-4-fluorophenyl)(phenyl)methanone

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

3-chloro-4-fluorobenzoyl chloride (1.0 g), benzene (2 ml) and ferric chloride (0.28 g) were heated to reflux for 16 h then diluted with water, extracted with ethyl acetate and the organics dried (MgSO4) and evaporated under reduced pressure to give the subtitle compound as a brown solid (0.8 g).

Workup

  1. temperatureto reflux for 16 h
  2. extractionextracted with ethyl acetate
  3. dry with materialthe organics dried (MgSO4)
  4. customevaporated under reduced pressure

Sources & evidence

ORD record
ord-eea1459a686f4bd9aac3986c2d36801b
Source dataset
uspto-grants-2012_04
Patent number
US08148572B2

Reaction notes

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