HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 2-{[(3-Chloro-4-fluorophenyl)thio]methyl}pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | Picolyl chloride hydrochloride | HCID 23392 | — |
| Reactant | 3-Chloro-4-fluorobenzene-1-thiol | HCID 2734197 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-{[(3-Chloro-4-fluorophenyl)thio]methyl}pyridine | HCID 68956052 | — |
Reaction Steps
2-Picolyl chloride hydrochloride (3.03 g) was added to a stirred suspension of 3-chloro-4-fluorobenzenethiol (3.0 g) and cesium carbonate (12.0 g) in DMF (50 ml) and the mixture stirred at RT overnight. Mixture poured into water, organics extracted into ether and the ether extracts washed (brine), dried (MgSO4) and evaporated under reduced pressure to a green oil (4.0 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08148572B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-28cd284ea8cb470399a3001344abcd9f |
| Source note | uspto-grants-2012_04 |