Diiodomethane → 2-Iodo-1,3-dinitrobenzene

To a dispersion of 2,6-dinitroaniline (4.00 g, 0.021 mol) in diiodomethane (24 mL, 0.297 mol) isoamylnitrite (15 mL, 0.112 mol) was added (Smith et al., 1990, which is incorporated herein by reference). The mixture was stirred at room temperature for one hour, and then heated at 105° C. for eight hours. The excess of diiodomethane was removed in high vacuo. The residue was diluted with acetyl acetate (10 mL). Silica (ca 30 mL, mesh 230-400 Å) was added; the mixture was concentrated in vacuo and purified by column chromatography to yield 1-iodo-2,6-dinitrobenzene (3.21 g, 52%). 1H NMR (400 MHz, CDCl3): δ 7.84 (d, 2H, J=8.0 Hz), 7.67 (t, 1H, J=8.0 Hz).

1. temperatureheated at 105° C. for eight hours
2. customThe excess of diiodomethane was removed in high vacuo
3. additionThe residue was diluted with acetyl acetate (10 mL)
4. additionSilica (ca 30 mL, mesh 230-400 Å) was added
5. concentrationthe mixture was concentrated in vacuo
6. custompurified by column chromatography

ORD record

ord-a9652c748f0b42b79222e6d7d11b202b

Source dataset

uspto-grants-2012_04

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08148503B2