Trifluoroacetic acid → Trifluoroacetic acid

HRID 1687028Notes

Reaction equation

HRID 1687028 reaction equation
C(OC(=O)[NH:7][CH2:8][CH2:9][C:10](=[O:13])[NH:11][CH3:12])(C)(C)C.[F:15][C:16]([F:21])([F:20])[C:17]([OH:19])=[O:18]>ClCCl>[NH2:7][CH2:8][CH2:9][C:10]([NH:11][CH3:12])=[O:13].[C:17]([OH:19])([C:16]([F:21])([F:20])[F:15])=[O:18]

Participants

5

Reactant 2

HCID 6422Trifluoroacetic acidHCID 15546845HCID 15546845, compound

Product 2

HCID 6422Trifluoroacetic acidHCID 14889074N-Methyl-beta-alaninamide

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

(2-Methylcarbamoyl-ethyl)-carbamic acid tert-butyl ester (534 mg, 2.64 mmol) was dissolved in dichloromethane (10 mL) and the solution was treated with trifluoroacetic acid (3 mL). The reaction was allowed to stir overnight at room temperature. The solvent and excess TFA was then concentrated to afford 3-Amino-N-methyl-propionamide as a crude TFA salt. The crude material (270 mg) was used without further purification.

Workup

  1. concentrationThe solvent and excess TFA was then concentrated

Sources & evidence

ORD record
ord-1438ed47c2304646b695d60892eb66eb
Source dataset
uspto-grants-2012_04
Patent number
US08148391B2

Reaction notes

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