Tetrahydrofuran → HCID 67264023, compound

HRID 1687418Notes

Reaction equation

HRID 1687418 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([N+:18]([O-:20])=[O:19])=[C:7]([N:9](S(C)(=O)=O)[S:10]([CH3:13])(=[O:12])=[O:11])[CH:8]=1.O1CCCC1.[OH-].[Na+]>O>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([N+:18]([O-:20])=[O:19])=[C:7]([NH:9][S:10]([CH3:13])(=[O:12])=[O:11])[CH:8]=1

Participants

5

Reactant 3

HCID 8028TetrahydrofuranHCID 14798Sodium HydroxideHCID 67264251HCID 67264251, compound

Product 1

HCID 67264023HCID 67264023, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a solution of N-(5-Methoxy-2-nitro-phenyl)-N-(methylsulfonyl)methanesulfonamide (7.70 g) in Tetrahydrofuran (200 mL, 2 mol) was added 1 M of Sodium hydroxide in Water (50 mL). The mixture was stirred for 18 hours. The mixture was poured into a separatory funnel and the aqueous layer (bottom layer) was separated. The aqueous layer was washed with Ethyl Acetate (100 mL). The organic layers were combined, dried over magnesium sulfate, filtered and evaporated. N-(5-Methoxy-2-nitro-phenyl)-methanesulfonamide isolated as an orange solid (5.59 g, 76%).

Workup

  1. additionThe mixture was poured into a separatory funnel
  2. customthe aqueous layer (bottom layer) was separated
  3. washThe aqueous layer was washed with Ethyl Acetate (100 mL)
  4. dry with materialdried over magnesium sulfate
  5. filtrationfiltered
  6. customevaporated

Sources & evidence

ORD record
ord-231753c4654d46c1b85eebe2c336908d
Source dataset
uspto-grants-2012_04
Patent number
US08148391B2

Reaction notes

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