1-Methylpiperazine → 1-(1-Methoxy-2-nitro-6,7,8,9-tetrahydro-5H-benzocyclohepten-7-yl)-4-methyl-piperazine

HRID 1687489Notes

Reaction equation

HRID 1687489 reaction equation
[CH3:1][O:2][C:3]1[C:8]2[CH2:9][CH2:10][C:11](=O)[CH2:12][CH2:13][C:7]=2[CH:6]=[CH:5][C:4]=1[N+:15]([O-:17])=[O:16].[CH3:18][N:19]1[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1>>[CH3:1][O:2][C:3]1[C:8]2[CH2:9][CH2:10][CH:11]([N:22]3[CH2:23][CH2:24][N:19]([CH3:18])[CH2:20][CH2:21]3)[CH2:12][CH2:13][C:7]=2[CH:6]=[CH:5][C:4]=1[N+:15]([O-:17])=[O:16]

Participants

3

Reactant 2

HCID 531671-MethylpiperazineHCID 672641411-Methoxy-2-nitro-8,9-dihydro-5H-benzo[7]annulen-7(6H)-one

Product 1

HCID 672638441-(1-Methoxy-2-nitro-6,7,8,9-tetrahydro-5H-benzocyclohepten-7-yl)-4-methyl-piperazine

Procedure

1-(1-Methoxy-2-nitro-6,7,8,9-tetrahydro-5H-benzocyclohepten-7-yl)-4-methyl-piperazine was prepared from 1-methoxy-2-nitro-5,6,8,9-tetrahydro-benzocyclohepten-7-one and 1-methylpiperazine in a similar manner to Example 907e. Product was isolated as a brown film.

Workup

  1. customProduct was isolated as a brown film

Sources & evidence

ORD record
ord-2972b01006484bec9479d1ed78954c16
Source dataset
uspto-grants-2012_04
Patent number
US08148391B2

Reaction notes

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