Acetic Acid → HCID 86633984, compound

HRID 1687593Notes

Reaction equation

HRID 1687593 reaction equation
[NH2:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([NH:8][CH3:9])=[O:7])=[C:4]([NH:12][C:13]2[C:18]([Cl:19])=[CH:17][N:16]=[C:15]([Cl:20])[N:14]=2)[CH:3]=1.[C:21](OC(=O)C)(=[O:23])[CH3:22].C1COCC1.C(O)(=O)C>>[C:21]([NH:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([NH:8][CH3:9])=[O:7])=[C:4]([NH:12][C:13]2[C:18]([Cl:19])=[CH:17][N:16]=[C:15]([Cl:20])[N:14]=2)[CH:3]=1)(=[O:23])[CH3:22]

Participants

5

Reactant 4

HCID 176Acetic AcidHCID 7918Acetic AnhydrideHCID 8028TetrahydrofuranHCID 86633983HCID 86633983, compound

Product 1

HCID 86633984HCID 86633984, compound

Procedure

4-Amino-2-(2,5-dichloro-pyrimidin-4-ylamino)-N-methyl-benzamide (0.135 g, 0.000432 mol), Acetic anhydride (0.0428 mL, 0.000454 mol), THF (5 mL, 0.06 mol) and Acetic acid (0.024 mL, 0.43 mol) were stirred at rt for 16 h. Product isolated as white ppt (80 mg, 52%).

Workup

  1. customProduct isolated as white ppt (80 mg, 52%)

Sources & evidence

ORD record
ord-6cebe3c86baa44acb8e5e363ab44d834
Source dataset
uspto-grants-2012_04
Patent number
US08148391B2

Reaction notes

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