Tetrahydrofuran → HCID 86633990, compound

HRID 1687629Notes

Reaction equation

HRID 1687629 reaction equation
[C:1]([O:5][C:6](=[O:22])[NH:7][C:8]1[CH:21]=[CH:20][C:11]2[C:12]([CH3:19])([CH3:18])[CH2:13][CH2:14][C:15](=O)[NH:16][C:10]=2[CH:9]=1)([CH3:4])([CH3:3])[CH3:2].C1COCC1.COC1C=CC(P2(=S)SP(C3C=CC(OC)=CC=3)(=S)[S:37]2)=CC=1>>[C:1]([O:5][C:6](=[O:22])[NH:7][C:8]1[CH:21]=[CH:20][C:11]2[C:12]([CH3:19])([CH3:18])[CH2:13][CH2:14][C:15](=[S:37])[NH:16][C:10]=2[CH:9]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 3

HCID 8028TetrahydrofuranHCID 87949Lawesson's reagentHCID 67264257HCID 67264257, compound

Product 1

HCID 86633990HCID 86633990, compound

Procedure

(5,5-Dimethyl-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-8-yl)-carbamic acid tert-butyl ester (1.90 g, 0.00624 mol), THF (100 mL, 1 mol), and 2,4-Bis(4-methoxyphenyl)-2,4-dithioxo-1,3,2,4-dithiadiphosphetane (2.58 g, 6.4 mmol) were stirred at rt for 16 h. Title compound was obtained as a white solid (1.54 g, 77%), LCMS 321.21 (M+H).

Sources & evidence

ORD record
ord-a281784343854f5bbc3eb06208fff8f5
Source dataset
uspto-grants-2012_04
Patent number
US08148391B2

Reaction notes

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