反应详情

温度

20 °C

A solution of (4-isopropylthiazol-2-yl)(1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)methanone (example 66, step b) (0.28 g) and 2-(3-(bromomethyl)phenyl)ethanol (example 6, step a) (0.171 g) in acetonitrile (20 mL) was treated with triethylamine (0.276 mL) and the reaction mixture stirred for 2 hours at 20° C. The solvent was evaporated under reduced pressure and the residue partitioned between ethyl acetate and saturated sodium bicarbonate solution. The organic layer was dried over sodium sulphate, filtered and the solvent removed under reduced pressure. The crude product was purified by flash silica chromatography using 2.5% methanol in dichloromethane with 1% triethylamine as solvent to afford the subtitled compound. Yield 0.25 g.

1. customThe solvent was evaporated under reduced pressure
2. customthe residue partitioned between ethyl acetate and saturated sodium bicarbonate solution
3. dry with materialThe organic layer was dried over sodium sulphate
4. filtrationfiltered
5. customthe solvent removed under reduced pressure
6. customThe crude product was purified by flash silica chromatography