反应详情

Concentrated hydrochloric acid (5 mL) was added to a solution of 2-(4-(2,2-diethoxyethoxy)-2,3-difluorophenyl)ethanol (example 77, step c) (0.49 g) in 1,4-dioxane (10 mL) and the resulting mixture was stirred for 1 h. The mixture was carefully diluted with water (50 mL) and extracted with ethyl acetate (3×50 mL). The combined organics were washed with water (50 mL) and brine (50 mL), dried over sodium sulphate, filtered and evaporated to give the subtitled compound, which was used directly. Yield 0.31 g.

1. extractionextracted with ethyl acetate (3×50 mL)
2. washThe combined organics were washed with water (50 mL) and brine (50 mL)
3. dry with materialdried over sodium sulphate
4. filtrationfiltered
5. customevaporated