Dimethylformamide dimethyl acetal → HCID 11207982, compound

HRID 1689731Notes

Reaction equation

HRID 1689731 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([Br:8])=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10].CO[CH:14](OC)[N:15]([CH3:17])[CH3:16]>C1(C)C=CC=CC=1>[Br:8][C:5]1[CH:6]=[CH:7][C:2](/[CH:1]=[CH:14]/[N:15]([CH3:17])[CH3:16])=[C:3]([N+:9]([O-:11])=[O:10])[CH:4]=1

Participants

4

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 1235464-Bromo-2-nitrotoluene

Product 1

HCID 11207982HCID 11207982, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

To a solution of 1-methyl-2-nitro-4-bromobenzene (17) (29.86 g, 138.2 mmol) in toluene (200 mL) was added dimethylformamide dimethylacetal (17.52 g, 138.2 mmol). The mixture was heated to reflux for 14 hours. After cooling to room temperature the mixture was concentrated under vacuum and the resulting oil was immediately used in the next reaction.

Workup

  1. temperatureThe mixture was heated
  2. temperatureto reflux for 14 hours
  3. concentrationwas concentrated under vacuum
  4. customthe resulting oil was immediately used in the next reaction

Sources & evidence

ORD record
ord-50fbeae33e454ce39cbc0786862b7eb5
Source dataset
uspto-grants-2012_04
Patent number
US08153622B2

Reaction notes

Loading…