Dimethylformamide dimethyl acetal → HCID 66906104, compound

HRID 1689753Notes

Reaction equation

HRID 1689753 reaction equation
[CH2:1]([O:3][C:4](=[O:11])[C:5](=[O:10])[CH2:6][CH:7]1[CH2:9][CH2:8]1)[CH3:2].CO[CH:14](OC)[N:15]([CH3:17])[CH3:16]>>[CH2:1]([O:3][C:4](=[O:11])[C:5](=[O:10])[C:6]([CH:7]1[CH2:9][CH2:8]1)=[CH:14][N:15]([CH3:17])[CH3:16])[CH3:2]

Participants

3

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 22285629Ethyl 3-cyclopropyl-2-oxopropanoate

Product 1

HCID 66906104HCID 66906104, compoundYield 102.1%

Procedure

A mixture of 3-cyclopropyl-2-oxo-propionic acid ethyl ester (6.4 mmol, 1.0 g) and dimethylformamide dimethylacetal (12.8 mmol, 2.0 mL) are combined and stirred at room temperature for 18 hours. The reaction is concentrated under reduced pressure to yield the title compound (1.38 g, 100%). LC-MS: 212.0 (M+1).

Workup

  1. concentrationThe reaction is concentrated under reduced pressure

Sources & evidence

ORD record
ord-fcb7d41b4a1f4cbc96f28e5590579263
Source dataset
uspto-grants-2012_04
Patent number
US08153624B2

Reaction notes

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