Hydrochloric Acid → HCID 66907679, compound

HRID 1690060Notes

Reaction equation

HRID 1690060 reaction equation
[ClH:1].[N:2]1([C:6]2[N:11]=[CH:10][C:9]([NH:12][C:13]([C:15]3[N:27]([CH2:28][C:29]4[CH:34]=[CH:33][CH:32]=[C:31]([F:35])[CH:30]=4)[C:18]4=[N:19][CH:20]=[C:21]([C:23]([F:26])([F:25])[F:24])[CH:22]=[C:17]4[CH:16]=3)=[O:14])=[CH:8][CH:7]=2)[CH2:5][CH2:4][CH2:3]1>ClCCl>[ClH:1].[N:2]1([C:6]2[N:11]=[CH:10][C:9]([NH:12][C:13]([C:15]3[N:27]([CH2:28][C:29]4[CH:34]=[CH:33][CH:32]=[C:31]([F:35])[CH:30]=4)[C:18]4=[N:19][CH:20]=[C:21]([C:23]([F:24])([F:25])[F:26])[CH:22]=[C:17]4[CH:16]=3)=[O:14])=[CH:8][CH:7]=2)[CH2:5][CH2:4][CH2:3]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 25094231HCID 25094231, compound

Product 1

HCID 66907679HCID 66907679, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

2.6 mL of a 2M solution of hydrochloric acid is added to a solution of 1.2 g of N-[6-(azetidin-1-yl)pyridin-3-yl]-5-trifluoromethyl-1-(3-fluorobenzyl)-1H-pyrrolo[2,3-b]pyridine-2-carboxamide, prepared in the preceding stage, in 50 mL of dichloromethane. The solution is concentrated to dryness and the resultant solid is recrystallized from ethanol. In this way we isolate 0.62 g of the expected salt.

Workup

  1. concentrationThe solution is concentrated to dryness
  2. customthe resultant solid is recrystallized from ethanol

Sources & evidence

ORD record
ord-ece6392b3d2349159640589c7ba7f150
Source dataset
uspto-grants-2012_04
Patent number
US08153650B2

Reaction notes

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