Hydrochloric Acid → HCID 57431528, compound

HRID 1690067Notes

Reaction equation

HRID 1690067 reaction equation
[N:1]1([C:6]2[N:11]=[CH:10][C:9]([NH:12]C(OC(C)(C)C)=O)=[C:8]([C:20]([F:23])([F:22])[F:21])[CH:7]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1.C(OCC)C.[ClH:29]>O1CCOCC1>[ClH:29].[N:1]1([C:6]2[N:11]=[CH:10][C:9]([NH2:12])=[C:8]([C:20]([F:23])([F:21])[F:22])[CH:7]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 57431527HCID 57431527, compound

Product 1

HCID 57431528HCID 57431528, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A solution of 1 g (3.02 mmol) of 6-(pyrrolidin-1-yl)-4-trifluoromethyl-3-(terbutoxycarbonylamino)pyridine, prepared in the preceding stage, in 11 mL of 4N hydrochloric acid in dioxane, is stirred for 5 hours under reflux. Then 200 mL of ethyl ether is added to the cooled reaction mixture. 0.8 g of a precipitate is collected by filtration.

Workup

  1. temperatureunder reflux
  2. filtration0.8 g of a precipitate is collected by filtration

Sources & evidence

ORD record
ord-93babe51958f433eaf743b6c66ce1abf
Source dataset
uspto-grants-2012_04
Patent number
US08153650B2

Reaction notes

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