2-(3-Azabicyclo[3.2.0]hept-3-yl)-5-nitropyridine → 6-(3-Azabicyclo[3.2.0]hept-3-yl)-3-aminopyridine

HRID 1690072Notes

Reaction equation

HRID 1690072 reaction equation
[CH:1]12[CH2:7][CH2:6][CH:5]1[CH2:4][N:3]([C:8]1[CH:13]=[CH:12][C:11]([N+:14]([O-])=O)=[CH:10][N:9]=1)[CH2:2]2>[Pd]>[CH:5]12[CH2:6][CH2:7][CH:1]1[CH2:2][N:3]([C:8]1[N:9]=[CH:10][C:11]([NH2:14])=[CH:12][CH:13]=1)[CH2:4]2

Participants

3

Reactant 1

HCID 669078962-(3-Azabicyclo[3.2.0]hept-3-yl)-5-nitropyridine

Product 1

HCID 591900896-(3-Azabicyclo[3.2.0]hept-3-yl)-3-aminopyridineYield 92.2%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

According to a procedure similar to that described in Stage 14.2, starting from 0.12 g (0.55 mmol) of 2-(3-azabicyclo[3.2.0]hept-3-yl)-5-nitropyridine, prepared in the preceding stage, and 0.17 g of palladium on charcoal at 10%, we obtain 0.096 g of the expected compound.

Sources & evidence

ORD record
ord-7b60695ef7f847f5a3c2790698bd76eb
Source dataset
uspto-grants-2012_04
Patent number
US08153650B2

Reaction notes

Loading…