4-Methoxy-2-(pyrrolidin-1-yl)-5-aminopyridine → N-[4-Methoxy-6-(pyrrolidin-1-yl)pyridin-3-yl]-5-trifluoromethyl-1-[(4-pyridyl)methyl]-1H-pyrrolo[2,3-b]pyridine-2-carboxamide
Reaction equation
[NH2:1][C:2]1[C:3]([O:13][CH3:14])=[CH:4][C:5]([N:8]2[CH2:12][CH2:11][CH2:10][CH2:9]2)=[N:6][CH:7]=1.[F:15][C:16]([F:37])([F:36])[C:17]1[CH:18]=[C:19]2[CH:25]=[C:24]([C:26](O)=[O:27])[N:23]([CH2:29][C:30]3[CH:35]=[CH:34][N:33]=[CH:32][CH:31]=3)[C:20]2=[N:21][CH:22]=1>>[CH3:14][O:13][C:3]1[CH:4]=[C:5]([N:8]2[CH2:12][CH2:11][CH2:10][CH2:9]2)[N:6]=[CH:7][C:2]=1[NH:1][C:26]([C:24]1[N:23]([CH2:29][C:30]2[CH:35]=[CH:34][N:33]=[CH:32][CH:31]=2)[C:20]2=[N:21][CH:22]=[C:17]([C:16]([F:15])([F:36])[F:37])[CH:18]=[C:19]2[CH:25]=1)=[O:27]Participants
3
Reactant 2
Product 1
Procedure
The method described in Example 12.3 is followed, starting from 5-amino-4-methoxy-2-(pyrrolidin-1-yl)pyridine, prepared in the preceding stage, and 5-trifluoromethyl-1-[(4-pyridyl)methyl]-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid prepared in Stage 9.2.
Sources & evidence
- ORD record
- ord-e1c4f342da7e40eea8014998198db853
- Source dataset
- uspto-grants-2012_04
- Patent number
- US08153650B2
Reaction notes
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