反应详情

温度

70 °C

1-(4-Hydroxyphenyl)ethanone (15.0 g, 110 mmol) was dissolved in acetone (125 mL). The resultant mixture was sequentially added with potassium carbonate (30.4 g, 220 mmol) and 1-methylethyl iodide (16.5 mL, 165 mmol) and then stirred at 70° C. for 8 hours. The reaction solution was filtered, washed with acetone, and concentrated in vacuo. The obtained residue was added with water and ethyl acetate, and then extracted with ethyl acetate. The organic layer was washed with 1N aqueous solution of sodium hydroxide and brine, dried using anhydrous sodium sulfate, and concentrated in vacuo. 1-[4-(1-Methylethoxy)phenyl]ethanone (18.2 g, yield 93%) was obtained as a white crystal.

1. filtrationThe reaction solution was filtered
2. washwashed with acetone
3. concentrationconcentrated in vacuo
4. additionThe obtained residue was added with water and ethyl acetate
5. extractionextracted with ethyl acetate
6. washThe organic layer was washed with 1N aqueous solution of sodium hydroxide and brine
7. customdried
8. concentrationconcentrated in vacuo