Potassium Carbonate → HCID 59201054, compound

Participants

Reaction Steps

To a solution of (4-(4-(1,1,1,3,3,3-hexafluoro-2-(methoxymethoxy)propan-2-yl)-2-propylphenoxy)pyridin-2-yl)methyl acetate (221 mg, 446 μmol) in methanol (3 mL), potassium carbonate (123 mg) was added at room temperature and the resultant mixture was stirred. After completion of the reaction, the reaction solution was concentrated in vacuo. The residue was neutralized by adding water and 2 mol/L of hydrochloric acid at room temperature, extracted with ethyl acetate, and then concentrated in vacuo. The obtained residue was purified using silica-gel column chromatography (hexane/ethyl acetate) and the title compound (167 mg, yield 83%) was obtained as a colorless oil.

Provenance & Evidence