Potassium Carbonate → HCID 59201054, compound

HRID 1690158Notes

Reaction equation

HRID 1690158 reaction equation
C([O:4][CH2:5][C:6]1[CH:11]=[C:10]([O:12][C:13]2[CH:18]=[CH:17][C:16]([C:19]([O:28][CH2:29][O:30][CH3:31])([C:24]([F:27])([F:26])[F:25])[C:20]([F:23])([F:22])[F:21])=[CH:15][C:14]=2[CH2:32][CH2:33][CH3:34])[CH:9]=[CH:8][N:7]=1)(=O)C.C(=O)([O-])[O-].[K+].[K+]>CO>[F:23][C:20]([F:21])([F:22])[C:19]([C:16]1[CH:17]=[CH:18][C:13]([O:12][C:10]2[CH:9]=[CH:8][N:7]=[C:6]([CH2:5][OH:4])[CH:11]=2)=[C:14]([CH2:32][CH2:33][CH3:34])[CH:15]=1)([O:28][CH2:29][O:30][CH3:31])[C:24]([F:27])([F:26])[F:25]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 59200928HCID 59200928, compound

Product 1

HCID 59201054HCID 59201054, compoundYield 83%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of (4-(4-(1,1,1,3,3,3-hexafluoro-2-(methoxymethoxy)propan-2-yl)-2-propylphenoxy)pyridin-2-yl)methyl acetate (221 mg, 446 μmol) in methanol (3 mL), potassium carbonate (123 mg) was added at room temperature and the resultant mixture was stirred. After completion of the reaction, the reaction solution was concentrated in vacuo. The residue was neutralized by adding water and 2 mol/L of hydrochloric acid at room temperature, extracted with ethyl acetate, and then concentrated in vacuo. The obtained residue was purified using silica-gel column chromatography (hexane/ethyl acetate) and the title compound (167 mg, yield 83%) was obtained as a colorless oil.

Workup

  1. customAfter completion of the reaction
  2. concentrationthe reaction solution was concentrated in vacuo
  3. additionby adding water and 2 mol/L of hydrochloric acid at room temperature
  4. extractionextracted with ethyl acetate
  5. concentrationconcentrated in vacuo
  6. customThe obtained residue was purified

Sources & evidence

ORD record
ord-c9cf3408237a4223af2a3f07af711185
Source dataset
uspto-grants-2012_04
Patent number
US08153634B2

Reaction notes

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