反应详情

To a solution of 5-(4-(1,1,1,3,3,3-hexafluoro-2-(methoxymethoxy)propan-2-yl)-2-propylphenoxy)-2-nitrobenzaldehyde (576 mg, 1.16 mmol) in methanol (5.8 mL), sodium borohydride (46 mg, 1.22 mmol) was added under ice-cold conditions, and the resultant mixture was stirred under ice-cold conditions for 20 minutes. The reaction solution was added with water and 5% aqueous solution of hydrochloric acid and extracted with ethyl acetate. The organic layer was washed with a saturated aqueous solution of sodium hydrogen carbonate and brine, and dried over anhydrous sodium sulfate. (5-(4-(1,1,1,3,3,3-Hexafluoro-2-(methoxymethoxy)propan-2-yl)-2-propylphenoxy)-2-nitrophenyl) methanol (575 mg, yield 99%) was obtained as a yellow oil.

1. extractionextracted with ethyl acetate
2. washThe organic layer was washed with a saturated aqueous solution of sodium hydrogen carbonate and brine
3. dry with materialdried over anhydrous sodium sulfate