反应详情

To a solution of 5-(methoxymethoxy)-2-methylpyridin-4-ylboronic acid (500 mg, 2.54 mmol) in tetrahydrofuran (12.7 mL), an aqueous solution of hydroxide peroxide (purity 30%) (2.9 mL, 25.4 mmol) was added at room temperature, and the resultant mixture was stirred at room temperature for 4 hours. The reaction solution was added with a saturated aqueous solution of sodium persulfate and concentrated in vacuo. The obtained residue was washed and filtered with chloroform/methanol, and 5-(methoxymethoxy)-2-methylpyridin-4(1H)-one (440 mg, yield >100%) was obtained as a yellow amorphous.

1. concentrationconcentrated in vacuo
2. washThe obtained residue was washed
3. filtrationfiltered with chloroform/methanol