Hydrochloric Acid → 3-amino-N-(isoquinolin-6-yl)-3-(thiophen-3-yl)propanamide dihydrochloride

HRID 1690253Notes

Reaction equation

HRID 1690253 reaction equation
[CH:1]1[C:10]2[C:5](=[CH:6][C:7]([NH:11][C:12](=[O:28])[CH2:13][CH:14]([NH:20]C(=O)OC(C)(C)C)[C:15]3[CH:19]=[CH:18][S:17][CH:16]=3)=[CH:8][CH:9]=2)[CH:4]=[CH:3][N:2]=1.[ClH:29]>C(Cl)Cl>[ClH:29].[ClH:29].[NH2:20][CH:14]([C:15]1[CH:19]=[CH:18][S:17][CH:16]=1)[CH2:13][C:12]([NH:11][C:7]1[CH:6]=[C:5]2[C:10](=[CH:9][CH:8]=1)[CH:1]=[N:2][CH:3]=[CH:4]2)=[O:28]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59161737Tert-butyl 3-(isoquinolin-6-ylamino)-3-oxo-1-(thiophen-3-yl)propylcarbamate

Product 1

HCID 669057643-amino-N-(isoquinolin-6-yl)-3-(thiophen-3-yl)propanamide dihydrochloride

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To tert-butyl 3-(isoquinolin-6-ylamino)-3-oxo-1-(thiophen-3-yl)propylcarbamate (E5) in CH2Cl2 was added HCl (4N in dioxane), and the solution was stirred for 8 hours. The solvents were evaporated to give 3-amino-N-(isoquinolin-6-yl)-3-(thiophen-3-yl)propanamide dihydrochloride (E6).

Workup

  1. customThe solvents were evaporated

Sources & evidence

ORD record
ord-d16cb21d3f16432a82d8a6a8af16cd38
Source dataset
uspto-grants-2012_04
Patent number
US08153656B2

Reaction notes

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