HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → NH3 MeOH EtOH
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | Methyl 3-(dimethylamino)-2-(thiophen-3-yl)propanoate | HCID 59161743 | — |
| Solvent | Methanol tetrahydrofuran water | HCID 21892291 | — |
| Product | 3-(Dimethylamino)-2-(thiophen-3-yl)propanoic acid | HCID 59161746 | — |
| Product | NH3 MeOH EtOH | HCID 86638423 | 10% |
Reaction Steps
To methyl 3-(dimethylamino)-2-(thiophen-3-yl)propanoate (E42) in THF/H2O/MeOH was added LiOH*H2O, and the solution was stirred for 12 hours. AcOH was added and the solvents were evaporated. Column chromatography (SiO2, 10-15% 2M NH3-MeOH/EtOH) gave pure 3-(dimethylamino)-2-(thiophen-3-yl)propanoic acid (E43).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08153656B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-58b4bc0e79224096bbf3fb9949783f68 |
| Source note | uspto-grants-2012_04 |