huagongshe.com
HRID1690255

反应详情

EQUATION

反应方程式

HRID 1690255 的结构方程式

REACTANTS

反应物

4
结构：CC(=O)O
HCID176

Acetic Acid

C2H4O2

结构：O
HCID962

Water

H2O

结构：[Li+].[OH-]
HCID3939

Lithium hydroxide anhydrous

HLiO

结构：COC(=O)C(CN(C)C)c1ccsc1
HCID59161743

未命名化合物

PRODUCTS

生成物

2
结构：CN(C)CC(C(=O)O)c1ccsc1
HCID59161746

未命名化合物

结构：CCO.CO.N
HCID86638423

未命名化合物

收率 10%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：C1CCOC1.CO.O
溶剂HCID21892291

未命名化合物

PROCEDURE

实验过程

To methyl 3-(dimethylamino)-2-(thiophen-3-yl)propanoate (E42) in THF/H2O/MeOH was added LiOH*H2O, and the solution was stirred for 12 hours. AcOH was added and the solvents were evaporated. Column chromatography (SiO2, 10-15% 2M NH3-MeOH/EtOH) gave pure 3-(dimethylamino)-2-(thiophen-3-yl)propanoic acid (E43).

WORKUP

后处理

  1. customthe solvents were evaporated