Hydrochloric Acid → 3-Amino-2-(thiophen-3-yl)propanoic acid

HRID 1690258Notes

Reaction equation

HRID 1690258 reaction equation
O=C1C2C(=CC=CC=2)C(=O)[N:3]1[CH2:12][CH:13]([C:18]1[CH:22]=[CH:21][S:20][CH:19]=1)[C:14]([O:16]C)=[O:15].Cl>>[NH2:3][CH2:12][CH:13]([C:18]1[CH:22]=[CH:21][S:20][CH:19]=1)[C:14]([OH:16])=[O:15]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 59161752Methyl 3-(1,3-dioxoisoindolin-2-yl)-2-(thiophen-3-yl)propanoate

Product 1

HCID 197566333-Amino-2-(thiophen-3-yl)propanoic acid

Procedure

To methyl 3-(1,3-dioxoisoindolin-2-yl)-2-(thiophen-3-yl)propanoate (E45) was added 6 N HCl, and the solution was refluxed for 4 hours. The solvents were evaporated to give 3-amino-2-(thiophen-3-yl)propanoic acid (E46).

Workup

  1. temperaturethe solution was refluxed for 4 hours
  2. customThe solvents were evaporated

Sources & evidence

ORD record
ord-7a781bda5c2d4e04bf8b7de6989c0285
Source dataset
uspto-grants-2012_04
Patent number
US08153656B2

Reaction notes

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