2,6-Xylyl isocyanate → 1-Cyclohexyl-3-(2,6-dimethyl-phenyl)-1-(2-phenyl-2H-indazol-3-yl)-urea

HRID 1690513Notes

Reaction equation

HRID 1690513 reaction equation
[CH:1]1([NH:7][C:8]2[N:9]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[N:10]=[C:11]3[C:16]=2[CH:15]=[CH:14][CH:13]=[CH:12]3)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[N:23]([C:26]1[C:31]([CH3:32])=[CH:30][CH:29]=[CH:28][C:27]=1[CH3:33])=[C:24]=[O:25]>C1(C)C=CC=CC=1>[CH:1]1([N:7]([C:8]2[N:9]([C:17]3[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=3)[N:10]=[C:11]3[C:16]=2[CH:15]=[CH:14][CH:13]=[CH:12]3)[C:24]([NH:23][C:26]2[C:27]([CH3:33])=[CH:28][CH:29]=[CH:30][C:31]=2[CH3:32])=[O:25])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 987872,6-Xylyl isocyanateHCID 12318206N-Cyclohexyl-2-phenyl-2H-indazol-3-amine

Product 1

HCID 451106171-Cyclohexyl-3-(2,6-dimethyl-phenyl)-1-(2-phenyl-2H-indazol-3-yl)-urea

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

In analogy to the procedure described in example 1.2, cyclohexyl-(2-phenyl-2H-indazol-3-yl)-amine (example 1.1) was reacted with 2-isocyanato-1,3-dimethyl-benzene ([28556-81-2]) in toluene for 72 h under reflux conditions to give the title compound as yellow oil. MS: m/e=439.3 [M+H+].

Sources & evidence

ORD record
ord-a03121c44e3149f7b2a0a96fa6ca83bd
Source dataset
uspto-grants-2012_04
Patent number
US08153663B2

Reaction notes

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