Benzylamine → Benzyl-[2-(4-chloro-phenyl)-2H-indazol-3-yl]-amine

HRID 1690516Notes

Reaction equation

HRID 1690516 reaction equation
C([N:5]([C:15]1[N:16]([C:24]2[CH:29]=[CH:28][C:27]([Cl:30])=[CH:26][CH:25]=2)[N:17]=[C:18]2[C:23]=1[CH:22]=[CH:21][CH:20]=[CH:19]2)[C:6](NC1CCCCC1)=O)CCC.C(N)[C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1>CN1CCCC1=O>[CH2:6]([NH:5][C:15]1[N:16]([C:24]2[CH:29]=[CH:28][C:27]([Cl:30])=[CH:26][CH:25]=2)[N:17]=[C:18]2[C:23]=1[CH:22]=[CH:21][CH:20]=[CH:19]2)[C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1

Participants

4

Reactant 2

HCID 7504BenzylamineHCID 451106161-Butyl-1-[2-(4-chloro-phenyl)-2H-indazol-3-yl]-3-cyclohexyl-urea

Product 1

HCID 66905008Benzyl-[2-(4-chloro-phenyl)-2H-indazol-3-yl]-amine

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

In analogy to the procedure described in example 4.1, 3-chloro-2-(4-chloro-phenyl)-2H-indazole (Ardakani, Manouchehr; Smalley, Robert K.; Smith, Richard H., Synthesis (1979), (4), 308-9) was reacted with benzylamine in N-methyl 2-pyrrolidone for 48 h at 175° C. in a sealed tube to give the title compound as yellow oil. MS: m/e=334.4 [M+H+].

Sources & evidence

ORD record
ord-27be15dfde82427995153ed148984747
Source dataset
uspto-grants-2012_04
Patent number
US08153663B2

Reaction notes

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