Cyclohexyl isocyanate → 1-Benzyl-1-[2-(4-chloro-phenyl)-2H-indazol-3-yl]-3-cyclohexyl-urea

HRID 1690517Notes

Reaction equation

HRID 1690517 reaction equation
[CH2:1]([NH:8][C:9]1[N:10]([C:18]2[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][CH:19]=2)[N:11]=[C:12]2[C:17]=1[CH:16]=[CH:15][CH:14]=[CH:13]2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH:25]1([N:31]=[C:32]=[O:33])[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]1>C1(C)C=CC=CC=1>[CH2:1]([N:8]([C:9]1[N:10]([C:18]2[CH:19]=[CH:20][C:21]([Cl:24])=[CH:22][CH:23]=2)[N:11]=[C:12]2[C:17]=1[CH:16]=[CH:15][CH:14]=[CH:13]2)[C:32]([NH:31][CH:25]1[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]1)=[O:33])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 18502Cyclohexyl isocyanateHCID 66905008Benzyl-[2-(4-chloro-phenyl)-2H-indazol-3-yl]-amine

Product 1

HCID 451107431-Benzyl-1-[2-(4-chloro-phenyl)-2H-indazol-3-yl]-3-cyclohexyl-urea

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

In analogy to the procedure described in example 1.2, benzyl-[2-(4-chloro-phenyl)-2H-indazol-3-yl]-amine was reacted with cyclohexylisocyanate ([3173-53-3]) in toluene for 48 h under reflux conditions to give the title compound as yellow solid. MS: m/e=459.4 [M+H+].

Sources & evidence

ORD record
ord-1e5ca2a3fc2a4073bc2987c9bb4e32b7
Source dataset
uspto-grants-2012_04
Patent number
US08153663B2

Reaction notes

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