Ethyl 3-isocyanatobenzoate → HCID 66905646, compound

HRID 1690518Notes

Reaction equation

HRID 1690518 reaction equation
[CH:1]1([NH:7][C:8]2[N:9]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[N:10]=[C:11]3[C:16]=2[CH:15]=[CH:14][CH:13]=[CH:12]3)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH2:23]([O:25][C:26](=[O:36])[C:27]1[CH:32]=[CH:31][CH:30]=[C:29]([N:33]=[C:34]=[O:35])[CH:28]=1)C>C1(C)C=CC=CC=1>[CH3:23][O:25][C:26](=[O:36])[C:27]1[CH:32]=[CH:31][CH:30]=[C:29]([NH:33][C:34]([N:7]([CH:1]2[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]2)[C:8]2[N:9]([C:17]3[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=3)[N:10]=[C:11]3[C:16]=2[CH:15]=[CH:14][CH:13]=[CH:12]3)=[O:35])[CH:28]=1

Participants

4

Reactant 2

HCID 589806Ethyl 3-isocyanatobenzoateHCID 12318206N-Cyclohexyl-2-phenyl-2H-indazol-3-amine

Product 1

HCID 66905646HCID 66905646, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

In analogy to the procedure described in example 1.2, cyclohexyl-(2-phenyl-2H-indazol-3-yl)-amine (example 1.1) was reacted with 3-isocyanato-benzoic acid ethyl ester ([41221-47-0]) in toluene for 72 h under reflux conditions to give the title compound as yellow oil. MS: m/e=469.3 [M+H+].

Sources & evidence

ORD record
ord-97e643c263284e2dba5cd3e172f51b61
Source dataset
uspto-grants-2012_04
Patent number
US08153663B2

Reaction notes

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