Lithium Hydroxide → HCID 45110744, compound

HRID 1690519Notes

Reaction equation

HRID 1690519 reaction equation
C[O:2][C:3](=[O:35])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([NH:10][C:11]([N:13]([CH:29]2[CH2:34][CH2:33][CH2:32][CH2:31][CH2:30]2)[C:14]2[N:15]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[N:16]=[C:17]3[C:22]=2[CH:21]=[CH:20][CH:19]=[CH:18]3)=[O:12])[CH:5]=1.[OH-].[Li+]>C1COCC1.CO>[CH:29]1([N:13]([C:14]2[N:15]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[N:16]=[C:17]3[C:22]=2[CH:21]=[CH:20][CH:19]=[CH:18]3)[C:11](=[O:12])[NH:10][C:6]2[CH:5]=[C:4]([CH:9]=[CH:8][CH:7]=2)[C:3]([OH:35])=[O:2])[CH2:34][CH2:33][CH2:32][CH2:31][CH2:30]1

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 66905646HCID 66905646, compound

Product 1

HCID 45110744HCID 45110744, compound

Reagents, catalysts & solvents 1

HCID 21899815MeOH tetrahydrofuranSolvent

Procedure

In analogy to the procedure described in example 2.2, 3-[3-cyclohexyl-3-(2-phenyl-2H-indazol-3-yl)-ureido]-benzoic acid methyl ester was treated with 1 N aqueous lithium hydroxide solution in THF/MeOH 1/1 for 5 h at ambient temperature to give the title compound as yellow foam. MS: m/e=455.1 [M+H+].

Sources & evidence

ORD record
ord-80875739aa4d4724b057f67f6bfbd3f6
Source dataset
uspto-grants-2012_04
Patent number
US08153663B2

Reaction notes

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