HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Hydroxide → 4-{3-Butyl-3-[2-(4-chloro-phenyl)-2H-indazol-3-yl]-ureido}-3-chloro-benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | 4-{3-Butyl-3-[2-(4-chloro-phenyl)-2H-indazol-3-yl]-ureido}-3-chloro-benzoic acid methyl ester | HCID 66905528 | — |
| Solvent | MeOH tetrahydrofuran | HCID 21899815 | — |
| Product | 4-{3-Butyl-3-[2-(4-chloro-phenyl)-2H-indazol-3-yl]-ureido}-3-chloro-benzoic acid | HCID 45110747 | — |
Reaction Steps
In analogy to the procedure described in example 2.2, 4-{3-butyl-3-[2-(4-chloro-phenyl)-2H-indazol-3-yl]-ureido}-3-chloro-benzoic acid methyl ester was treated with 1 N aqueous lithium hydroxide solution in THF/MeOH 1/1 for 14 h at ambient temperature to give the title compound as colorless foam. MS: m/e=496.1 [M−H−].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08153663B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-f6e50bc647ee4ccea44533ed0d9eb40c |
| Source note | uspto-grants-2012_04 |