Lithium Hydroxide → 4-[3-Cyclohexyl-3-(2-phenyl-2H-indazol-3-yl)-ureido]-3-methyl-benzoic acid

HRID 1690531Notes

Reaction equation

HRID 1690531 reaction equation
C[O:2][C:3](=[O:36])[C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:11]([N:13]([CH:29]2[CH2:34][CH2:33][CH2:32][CH2:31][CH2:30]2)[C:14]2[N:15]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[N:16]=[C:17]3[C:22]=2[CH:21]=[CH:20][CH:19]=[CH:18]3)=[O:12])=[C:6]([CH3:35])[CH:5]=1.[OH-].[Li+]>C1COCC1.CO>[CH:29]1([N:13]([C:14]2[N:15]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[N:16]=[C:17]3[C:22]=2[CH:21]=[CH:20][CH:19]=[CH:18]3)[C:11](=[O:12])[NH:10][C:7]2[CH:8]=[CH:9][C:4]([C:3]([OH:36])=[O:2])=[CH:5][C:6]=2[CH3:35])[CH2:30][CH2:31][CH2:32][CH2:33][CH2:34]1

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 669057094-[3-Cyclohexyl-3-(2-phenyl-2H-indazol-3-yl)-ureido]-3-methyl-benzoic acid methyl ester

Product 1

HCID 451108834-[3-Cyclohexyl-3-(2-phenyl-2H-indazol-3-yl)-ureido]-3-methyl-benzoic acid

Reagents, catalysts & solvents 1

HCID 21899815MeOH tetrahydrofuranSolvent

Procedure

In analogy to the procedure described in example 2.2, 4-[3-cyclohexyl-3-(2-phenyl-2H-indazol-3-yl)-ureido]-3-methyl-benzoic acid methyl ester was treated with 1 N aqueous lithium hydroxide solution in THF/MeOH 1/1 for 14 h at ambient temperature to give the title compound as off-white solid. MS: m/e=469.4 [M+H+].

Sources & evidence

ORD record
ord-346a278e6fe24ffa9c26eb767e29ded7
Source dataset
uspto-grants-2012_04
Patent number
US08153663B2

Reaction notes

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