HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Hydroxide → 3-Chloro-4-[3-cyclohexyl-3-(2-phenyl-2H-indazol-3-yl)-ureido]-benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | 3-Chloro-4-[3-cyclohexyl-3-(2-phenyl-2H-indazol-3-yl)-ureido]-benzoic acid methyl ester | HCID 66905722 | — |
| Solvent | MeOH tetrahydrofuran | HCID 21899815 | — |
| Product | 3-Chloro-4-[3-cyclohexyl-3-(2-phenyl-2H-indazol-3-yl)-ureido]-benzoic acid | HCID 45110884 | — |
Reaction Steps
In analogy to the procedure described in example 2.2, 3-chloro-4-[3-cyclohexyl-3-(2-phenyl-2H-indazol-3-yl)-ureido]-benzoic acid methyl ester was treated with 1 N aqueous lithium hydroxide solution in THF/MeOH 1/1 for 16 h at ambient temperature to give the title compound as off-white solid. MS: m/e=489.3 [M+H+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08153663B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-edbe67f714254477ac1b5ad6ff3452dc |
| Source note | uspto-grants-2012_04 |