Cyclohexyl isocyanate → 1-[2-(4-Chloro-phenyl)-2H-indazol-3-yl]-3-cyclohexyl-1-(2-methoxy-ethyl)-urea

HRID 1690543Notes

Reaction equation

HRID 1690543 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:16]([NH:17][CH2:18][CH2:19][O:20][CH3:21])=[C:15]3[C:10]([CH:11]=[CH:12][CH:13]=[CH:14]3)=[N:9]2)=[CH:4][CH:3]=1.[CH:22]1([N:28]=[C:29]=[O:30])[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]1>C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:16]([N:17]([CH2:18][CH2:19][O:20][CH3:21])[C:29]([NH:28][CH:22]3[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]3)=[O:30])=[C:15]3[C:10]([CH:11]=[CH:12][CH:13]=[CH:14]3)=[N:9]2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 18502Cyclohexyl isocyanateHCID 66905366[2-(4-Chloro-phenyl)-2H-indazol-3-yl]-(2-methoxy-ethyl)-amine

Product 1

HCID 451108871-[2-(4-Chloro-phenyl)-2H-indazol-3-yl]-3-cyclohexyl-1-(2-methoxy-ethyl)-urea

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

In analogy to the procedure described in example 1.2, [2-(4-chloro-phenyl)-2H-indazol-3-yl]-(2-methoxy-ethyl)-amine was reacted with cyclohexylisocyanate ([3173-53-3]) in toluene for 3 days under reflux conditions to give the title compound as brown foam. MS: m/e=427.4 [M+H+].

Sources & evidence

ORD record
ord-c42bac745712472eb7528a0511a541e4
Source dataset
uspto-grants-2012_04
Patent number
US08153663B2

Reaction notes

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