[2-(4-Chloro-phenyl)-2H-indazol-3-yl]-phenyl-amine → 3-Chloro-4-{3-[2-(4-chloro-phenyl)-2H-indazol-3-yl]-3-phenyl-ureido}-benzoic acid methyl ester

HRID 1690544Notes

Reaction equation

HRID 1690544 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:16]([NH:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[C:15]3[C:10]([CH:11]=[CH:12][CH:13]=[CH:14]3)=[N:9]2)=[CH:4][CH:3]=1.[CH3:24][O:25][C:26](=[O:37])[C:27]1[CH:32]=[CH:31][C:30]([N:33]=[C:34]=[O:35])=[C:29]([Cl:36])[CH:28]=1>C1(C)C=CC=CC=1>[CH3:24][O:25][C:26](=[O:37])[C:27]1[CH:32]=[CH:31][C:30]([NH:33][C:34]([N:17]([C:16]2[N:8]([C:5]3[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=3)[N:9]=[C:10]3[C:15]=2[CH:14]=[CH:13][CH:12]=[CH:11]3)[C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=2)=[O:35])=[C:29]([Cl:36])[CH:28]=1

Participants

4

Reactant 2

HCID 66905358[2-(4-Chloro-phenyl)-2H-indazol-3-yl]-phenyl-amineHCID 866402623-Chloro-4-isocyanato-benzoic acid methyl ester

Product 1

HCID 451110243-Chloro-4-{3-[2-(4-chloro-phenyl)-2H-indazol-3-yl]-3-phenyl-ureido}-benzoic acid methyl ester

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

In analogy to the procedure described in example 1.2, [2-(4-chloro-phenyl)-2H-indazol-3-yl]-phenyl-amine (example 15.1) was reacted with 3-chloro-4-isocyanato-benzoic acid methyl ester (example 9.1) in toluene for 7 days under reflux conditions to give the title compound as yellow foam. MS: m/e=530.7 [M+H+].

Sources & evidence

ORD record
ord-cedd423ebd99447aa0668a7c4d700315
Source dataset
uspto-grants-2012_04
Patent number
US08153663B2

Reaction notes

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