HuagongsheHuagongshe Chemistry Print Report · For research reference only
[2-(4-Chloro-phenyl)-2H-indazol-3-yl]-phenyl-amine → 3-Chloro-4-{3-[2-(4-chloro-phenyl)-2H-indazol-3-yl]-3-phenyl-ureido}-benzoic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | [2-(4-Chloro-phenyl)-2H-indazol-3-yl]-phenyl-amine | HCID 66905358 | — |
| Reactant | 3-Chloro-4-isocyanato-benzoic acid methyl ester | HCID 86640262 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 3-Chloro-4-{3-[2-(4-chloro-phenyl)-2H-indazol-3-yl]-3-phenyl-ureido}-benzoic acid methyl ester | HCID 45111024 | — |
Reaction Steps
In analogy to the procedure described in example 1.2, [2-(4-chloro-phenyl)-2H-indazol-3-yl]-phenyl-amine (example 15.1) was reacted with 3-chloro-4-isocyanato-benzoic acid methyl ester (example 9.1) in toluene for 7 days under reflux conditions to give the title compound as yellow foam. MS: m/e=530.7 [M+H+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08153663B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-cedd423ebd99447aa0668a7c4d700315 |
| Source note | uspto-grants-2012_04 |