Cyclohexyl isocyanate → 1-(3-Chloro-phenyl)-1-[2-(4-chloro-phenyl)-2H-indazol-3-yl]-3-cyclohexyl-urea

HRID 1690546Notes

Reaction equation

HRID 1690546 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH:8][C:9]2[N:10]([C:18]3[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][CH:19]=3)[N:11]=[C:12]3[C:17]=2[CH:16]=[CH:15][CH:14]=[CH:13]3)[CH:5]=[CH:6][CH:7]=1.[CH:25]1([N:31]=[C:32]=[O:33])[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]1>C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:3]=[C:4]([N:8]([C:9]2[N:10]([C:18]3[CH:19]=[CH:20][C:21]([Cl:24])=[CH:22][CH:23]=3)[N:11]=[C:12]3[C:17]=2[CH:16]=[CH:15][CH:14]=[CH:13]3)[C:32]([NH:31][CH:25]2[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]2)=[O:33])[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 18502Cyclohexyl isocyanateHCID 66905411(3-Chloro-phenyl)-[2-(4-chloro-phenyl)-2H-indazol-3-yl]-amine

Product 1

HCID 451110251-(3-Chloro-phenyl)-1-[2-(4-chloro-phenyl)-2H-indazol-3-yl]-3-cyclohexyl-urea

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

In analogy to the procedure described in example 1.2, (3-chloro-phenyl)-[2-(4-chloro-phenyl)-2H-indazol-3-yl]-amine was reacted with cyclohexylisocyanate ([3173-53-3]) in toluene for 3 d under reflux conditions to give the title compound as yellow foam. MS: m/e=479.3 [M+H+].

Sources & evidence

ORD record
ord-3eba4a2feefa4d688e4504bacf568a3d
Source dataset
uspto-grants-2012_04
Patent number
US08153663B2

Reaction notes

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