Lithium Hydroxide → 3-Chloro-4-[3-[2-(4-chloro-phenyl)-2H-indazol-3-yl]-3-(2-methoxy-ethyl)-ureido]-benzoic acid

HRID 1690548Notes

Reaction equation

HRID 1690548 reaction equation
C[O:2][C:3](=[O:35])[C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:11]([N:13]([C:18]2[N:19]([C:27]3[CH:32]=[CH:31][C:30]([Cl:33])=[CH:29][CH:28]=3)[N:20]=[C:21]3[C:26]=2[CH:25]=[CH:24][CH:23]=[CH:22]3)[CH2:14][CH2:15][O:16][CH3:17])=[O:12])=[C:6]([Cl:34])[CH:5]=1.[OH-].[Li+]>C(Cl)Cl.CCCCCCC>[Cl:34][C:6]1[CH:5]=[C:4]([CH:9]=[CH:8][C:7]=1[NH:10][C:11]([N:13]([C:18]1[N:19]([C:27]2[CH:28]=[CH:29][C:30]([Cl:33])=[CH:31][CH:32]=2)[N:20]=[C:21]2[C:26]=1[CH:25]=[CH:24][CH:23]=[CH:22]2)[CH2:14][CH2:15][O:16][CH3:17])=[O:12])[C:3]([OH:35])=[O:2]

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 669056003-Chloro-4-[3-[2-(4-chloro-phenyl)-2H-indazol-3-yl]-3-(2-methoxy-ethyl)-ureido]-benzoic acid methyl ester

Product 1

HCID 451110263-Chloro-4-[3-[2-(4-chloro-phenyl)-2H-indazol-3-yl]-3-(2-methoxy-ethyl)-ureido]-benzoic acid

Reagents, catalysts & solvents 1

HCID 21907733Dichloromethane heptaneSolvent

Procedure

In analogy to the procedure described in example 2.2, 3-chloro-4-[3-[2-(4-chloro-phenyl)-2H-indazol-3-yl]-3-(2-methoxy-ethyl)-ureido]-benzoic acid methyl ester was treated with 1 N aqueous lithium hydroxide solution in THF/MeOH 1/1 for 14 h at ambient temperature to give the title compound as yellow foam. MS: m/e=497.1 [M−H−].

Sources & evidence

ORD record
ord-2ce20b48a45e4191a87275626528f575
Source dataset
uspto-grants-2012_04
Patent number
US08153663B2

Reaction notes

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