Lithium Hydroxide → (3-Chloro-4-{3-[2-(4-chloro-phenyl)-2H-indazol-3-yl]-3-cyclohexyl-ureido}-phenyl)-acetic acid

HRID 1690552Notes

Reaction equation

HRID 1690552 reaction equation
C([O:3][C:4](=[O:39])[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([NH:12][C:13]([N:15]([C:22]2[N:23]([C:31]3[CH:36]=[CH:35][C:34]([Cl:37])=[CH:33][CH:32]=3)[N:24]=[C:25]3[C:30]=2[CH:29]=[CH:28][CH:27]=[CH:26]3)[CH:16]2[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]2)=[O:14])=[C:8]([Cl:38])[CH:7]=1)C.[OH-].[Li+]>C(OC(C)=O)(C)C.[Cl-].[Na+].O>[Cl:38][C:8]1[CH:7]=[C:6]([CH2:5][C:4]([OH:39])=[O:3])[CH:11]=[CH:10][C:9]=1[NH:12][C:13]([N:15]([C:22]1[N:23]([C:31]2[CH:36]=[CH:35][C:34]([Cl:37])=[CH:33][CH:32]=2)[N:24]=[C:25]2[C:30]=1[CH:29]=[CH:28][CH:27]=[CH:26]2)[CH:16]1[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21]1)=[O:14]

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 66905483(3-Chloro-4-{3-[2-(4-chloro-phenyl)-2H-indazol-3-yl]-3-cyclohexyl-ureido}-phenyl)-acetic acid ethyl ester

Product 1

HCID 45111027(3-Chloro-4-{3-[2-(4-chloro-phenyl)-2H-indazol-3-yl]-3-cyclohexyl-ureido}-phenyl)-acetic acid

Reagents, catalysts & solvents 1

HCID 131729614iPrOAc brineSolvent

Procedure

In analogy to the procedure described in example 2.2, (3-chloro-4-{3-[2-(4-chloro-phenyl)-2H-indazol-3-yl]-3-cyclohexyl-ureido}-phenyl)-acetic acid ethyl ester was treated with 1 N aqueous lithium hydroxide solution in THF/MeOH 1/1 for 14 h at ambient temperature to give the title compound as off-white solid. MS: m/e=536.8 [M+H+].

Sources & evidence

ORD record
ord-60af3ef0c4e34010aa171497e773c74b
Source dataset
uspto-grants-2012_04
Patent number
US08153663B2

Reaction notes

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