Lithium Hydroxide → 4-{3-[2-(4-Chloro-phenyl)-2H-indazol-3-yl]-3-cyclohexyl-ureido}-3-methyl-benzoic acid

HRID 1690554Notes

Reaction equation

HRID 1690554 reaction equation
C[O:2][C:3](=[O:37])[C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:11]([N:13]([C:20]2[N:21]([C:29]3[CH:34]=[CH:33][C:32]([Cl:35])=[CH:31][CH:30]=3)[N:22]=[C:23]3[C:28]=2[CH:27]=[CH:26][CH:25]=[CH:24]3)[CH:14]2[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]2)=[O:12])=[C:6]([CH3:36])[CH:5]=1.[OH-].[Li+]>C(OC(C)=O)(C)C.[Cl-].[Na+].O>[Cl:35][C:32]1[CH:33]=[CH:34][C:29]([N:21]2[C:20]([N:13]([CH:14]3[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]3)[C:11](=[O:12])[NH:10][C:7]3[CH:8]=[CH:9][C:4]([C:3]([OH:37])=[O:2])=[CH:5][C:6]=3[CH3:36])=[C:28]3[C:23]([CH:24]=[CH:25][CH:26]=[CH:27]3)=[N:22]2)=[CH:30][CH:31]=1

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 669055144-{3-[2-(4-Chloro-phenyl)-2H-indazol-3-yl]-3-cyclohexyl-ureido}-3-methyl-benzoic acid methyl ester

Product 1

HCID 451110284-{3-[2-(4-Chloro-phenyl)-2H-indazol-3-yl]-3-cyclohexyl-ureido}-3-methyl-benzoic acid

Reagents, catalysts & solvents 1

HCID 131729614iPrOAc brineSolvent

Procedure

In analogy to the procedure described in example 2.2, 4-{3-[2-(4-chloro-phenyl)-2H-indazol-3-yl]-3-cyclohexyl-ureido}-3-methyl-benzoic acid methyl ester was treated with 1 N aqueous lithium hydroxide solution in THF/MeOH 1/1 for 14 h at ambient temperature to give the title compound as yellow solid. MS: m/e=503.0 [M+H+].

Sources & evidence

ORD record
ord-a6e71b56884849509aab33bcda87f94c
Source dataset
uspto-grants-2012_04
Patent number
US08153663B2

Reaction notes

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