HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Hydroxide → {4-[3-Cyclohexyl-3-(2-phenyl-2H-indazol-3-yl)-ureido]-3-fluoro-phenoxy}-acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | {4-[3-Cyclohexyl-3-(2-phenyl-2H-indazol-3-yl)-ureido]-3-fluoro-phenoxy}-acetic acid methyl ester | HCID 66905457 | — |
| Solvent | iPrOAc brine | HCID 131729614 | — |
| Product | {4-[3-Cyclohexyl-3-(2-phenyl-2H-indazol-3-yl)-ureido]-3-fluoro-phenoxy}-acetic acid | HCID 45111176 | — |
Reaction Steps
In analogy to the procedure described in example 2.2, {4-[3-cyclohexyl-3-(2-phenyl-2H-indazol-3-yl)-ureido]-3-fluoro-phenoxy}-acetic acid methyl ester was treated with 1 N aqueous lithium hydroxide solution in THF/MeOH 1/1 for 1 h at 60° C. to give the title compound as off-white solid. MS: m/e=501.0 [M−H−].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08153663B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-b43c5be65c2241d9ae003c09d8cc563a |
| Source note | uspto-grants-2012_04 |