HRID1690559

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID3939

Lithium hydroxide anhydrous

HLiO

结构：COC(=O)COc1ccc(NC(=O)N(c2c3ccccc3nn2-c2ccccc2)C2CCCCC2)c(F)c1

HCID66905457

未命名化合物

PRODUCTS

生成物

结构：O=C(O)COc1ccc(NC(=O)N(c2c3ccccc3nn2-c2ccccc2)C2CCCCC2)c(F)c1

HCID45111176

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID131729614

未命名化合物

PROCEDURE

实验过程

In analogy to the procedure described in example 2.2, {4-[3-cyclohexyl-3-(2-phenyl-2H-indazol-3-yl)-ureido]-3-fluoro-phenoxy}-acetic acid methyl ester was treated with 1 N aqueous lithium hydroxide solution in THF/MeOH 1/1 for 1 h at 60° C. to give the title compound as off-white solid. MS: m/e=501.0 [M−H−].

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b43c5be65c2241d9ae003c09d8cc563a
来源数据集: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08153663B2
来源说明: uspto-grants-2012_04

反应 SMILES

C[O:2][C:3](=[O:38])[CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([NH:12][C:13]([N:15]([CH:31]2[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32]2)[C:16]2[N:17]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)[N:18]=[C:19]3[C:24]=2[CH:23]=[CH:22][CH:21]=[CH:20]3)=[O:14])=[C:8]([F:37])[CH:7]=1.[OH-].[Li+]>C(OC(C)=O)(C)C.[Cl-].[Na+].O>[CH:31]1([N:15]([C:16]2[N:17]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)[N:18]=[C:19]3[C:24]=2[CH:23]=[CH:22][CH:21]=[CH:20]3)[C:13](=[O:14])[NH:12][C:9]2[CH:10]=[CH:11][C:6]([O:5][CH2:4][C:3]([OH:38])=[O:2])=[CH:7][C:8]=2[F:37])[CH2:32][CH2:33][CH2:34][CH2:35][CH2:36]1