HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 3-(3-Fluoro-4-isocyanato-phenyl)-propionic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Triphosgene | HCID 94429 | — |
| Reactant | Tert-butyl 3-(4-amino-3-fluorophenyl)propanoate | HCID 66905628 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-(3-Fluoro-4-isocyanato-phenyl)-propionic acid tert-butyl ester | HCID 86640267 | — |
Reaction Steps
In analogy to the procedure described in example 9.1, 3-(4-amino-3-fluoro-phenyl)-propionic acid tert-butyl ester was reacted with triphosgene in the presence of Et3N in CH2Cl2 under reflux conditions for 20 h to give the title compound as yellow oil which was used in the next step without further purification. MS: m/e=265.1 [M+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08153663B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-e95c33b171d949e58ecc0610fb2bd4ec |
| Source note | uspto-grants-2012_04 |