HRID1690578

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID3939

Lithium hydroxide anhydrous

HLiO

结构：COC(=O)C(C)(C)c1ccc(NC(=O)N(c2c3ccccc3nn2-c2ccc(Cl)cc2)C2CCCCC2)c(F)c1

HCID66905694

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C(=O)O)c1ccc(NC(=O)N(c2c3ccccc3nn2-c2ccc(Cl)cc2)C2CCCCC2)c(F)c1

HCID45111331

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID131729614

未命名化合物

PROCEDURE

实验过程

In analogy to the procedure described in example 2.2, 2-(4-{3-[2-(4-chloro-phenyl)-2H-indazol-3-yl]-3-cyclohexyl-ureido}-3-fluoro-phenyl)-2-methyl-propionic acid methyl ester was treated with 1 N aqueous lithium hydroxide solution in THF/MeOH 1/1 for 14 h at ambient temperature to give the title compound as yellow solid. MS: m/e=549.3 [M+H+].

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-94049d0cfbac4ecfa15f7b021d74a536
来源数据集: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08153663B2
来源说明: uspto-grants-2012_04

反应 SMILES

C[O:2][C:3](=[O:40])[C:4]([C:7]1[CH:12]=[CH:11][C:10]([NH:13][C:14]([N:16]([C:23]2[N:24]([C:32]3[CH:37]=[CH:36][C:35]([Cl:38])=[CH:34][CH:33]=3)[N:25]=[C:26]3[C:31]=2[CH:30]=[CH:29][CH:28]=[CH:27]3)[CH:17]2[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]2)=[O:15])=[C:9]([F:39])[CH:8]=1)([CH3:6])[CH3:5].[OH-].[Li+]>C(OC(C)=O)(C)C.[Cl-].[Na+].O>[Cl:38][C:35]1[CH:36]=[CH:37][C:32]([N:24]2[C:23]([N:16]([CH:17]3[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22]3)[C:14](=[O:15])[NH:13][C:10]3[CH:11]=[CH:12][C:7]([C:4]([CH3:6])([CH3:5])[C:3]([OH:40])=[O:2])=[CH:8][C:9]=3[F:39])=[C:31]3[C:26]([CH:27]=[CH:28][CH:29]=[CH:30]3)=[N:25]2)=[CH:33][CH:34]=1